Buffalo
| Week | Opponent | Result |
|---|---|---|
| 1 | vs Wagner | W 69-7 |
| 2 | @ Nebraska | |
| 3 | vs Coastal Carolina | |
| 4 | @ Old Dominion | |
| 5 | vs Western Michigan | |
| 6 | @ Kent State | |
| 7 | vs Ohio | |
| 8 | @ Akron | |
| 9 | vs Bowling Green | |
| 10 | BYE | |
| 11 | @ Miami (OH) | |
| 12 | vs Northern Illinois | |
| 13 | @ Ball State | |
| 14 | BYE |
| Week | Opponent | Result |
|---|---|---|
| 1 | vs Robert Morris | W 38-10 |
| 2 | @ #15 Penn State | L 13-45 |
| 3 | @ Liberty | L 17-35 |
| 4 | vs Temple | W 38-22 |
| 5 | @ Miami (OH) | L 20-21 OT |
| 6 | vs Ohio | L 20-21 OT |
| 7 | BYE | |
| 8 | @ Akron | W 21-0 |
| 9 | vs Central Michigan | W 43-20 |
| 10 | @ Eastern Michigan | W 43-14 |
| 11 | BYE | |
| 12 | @ Kent State | L 27-30 |
| 13 | vs Toledo | W 49-30 |
| 14 | vs Bowling Green | W 49-7 |
| 15 | BYE | |
| Bahamas Bowl | vs Charlotte | W 31-9 |
| Week | Opponent | Result |
|---|---|---|
| 1 | vs Delaware State | W 48-10 |
| 2 | @ Temple | W 36-29 |
| 3 | vs Eastern Michigan | W 35-28 |
| 4 | @ Rutgers | W 42-13 |
| 5 | vs Army | L 13-42 |
| 6 | @ Central Michigan | W 34-24 |
| 7 | vs Akron | W 24-6 |
| 8 | @ Toledo | W 31-17 |
| 9 | BYE | |
| 10 | vs Miami (OH) | W 51-42 |
| 11 | vs Kent State | W 48-14 |
| 12 | @ Ohio | L 17-52 |
| 13 | @ Bowling Green | W 44-14 |
| 14 | vs Northern Illinois | L 29-30 (MAC Championship, Detroit) |
| 15 | BYE | |
| Dollar General Bowl | vs Troy | L 32-42 |
| Week | Opponent | Result |
|---|---|---|
| 1 | @ Minnesota | L 7-17 |
| 2 | @ Army | L 17-21 |
| 3 | vs Colgate | W 33-10 |
| 4 | vs Florida Atlantic | W 34-31 |
| 5 | @ Kent State | W 27-13 |
| 6 | vs Western Michigan | L 68-71 7OT |
| 7 | vs Northern Illinois | L 13-14 |
| 8 | @ Miami (OH) | L 14-24 |
| 9 | @ Akron | L 20-21 |
| 10 | BYE | |
| 11 | vs Bowling Green | W 38-28 |
| 12 | @ Ball State | W 40-24 |
| 13 | vs Ohio | W 31-24 |
| 14 | BYE | |
| 15 | BYE |
| Week | Opponent | Result |
|---|---|---|
| 1 | vs Albany | L 16-22 |
| 2 | BYE | |
| 3 | @ Nevada | L 14-38 |
| 4 | vs Army | W 23-20 (OT) |
| 5 | @ Boston College | L 3-35 |
| 6 | vs Kent State | L 20-44 |
| 7 | vs Ball State | L 21-31 |
| 8 | @ Northern Illinois | L 7-44 |
| 9 | vs Akron | W 41-20 |
| 10 | @ Ohio | L 10-34 |
| 11 | vs Miami (OH) | L 24-35 |
| 12 | @ #21 Western Michigan | L 0-38 |
| 13 | @ Bowling Green | L 19-27 |
| 14 | BYE | |
| 15 | BYE |
| Week | Opponent | Result |
|---|---|---|
| 1 | vs Albany | W 51-14 |
| 2 | @ Penn State | L 14-27 |
| 3 | @ Florida Atlantic | W 33-15 |
| 4 | vs Nevada | L 21-24 |
| 5 | vs Bowling Green | L 22-28 |
| 6 | BYE | |
| 7 | @ Central Michigan | L 14-41 |
| 8 | vs Ohio | W 41-17 |
| 9 | @ Miami (OH) | W 29-24 |
| 10 | @ Kent State | W 18-17 |
| 11 | vs Northern Illinois | L 30-41 |
| 12 | @ Akron | L 21-42 |
| 13 | vs Massachusetts | L 26-31 |
| 14 | BYE | |
| 15 | BYE |
| Week | Opponent | Result |
|---|---|---|
| 1 | vs Duquesne | W 38-28 |
| 2 | @ Army | L 39-47 |
| 3 | vs #8 Baylor | L 21-63 |
| 4 | vs Norfolk State | W 36-7 |
| 5 | vs Miami (OH) | W 35-27 |
| 6 | @ Bowling Green | L 35-36 |
| 7 | @ Eastern Michigan | L 27-37 |
| 8 | BYE | |
| 9 | vs Central Michigan | L 14-20 |
| 10 | BYE | |
| 11 | @ Ohio | L 14-37 |
| 12 | vs Akron | W 55-24 |
| 13 | vs Kent State | Canceled |
| 14 | @ Massachusetts | W 41-21 |
| 15 | BYE |